Hi,
Please go through the following article.
How to Use the Web Submission Process to Submit Suspicious Files
http://www.symantec.com/docs/TECH102419
Specifically this question
Q) How many files may I submit?
A) You may upload multiple files at once by using WinZip or WinRar. A zipped file must not be password-protected. The maximum size for one submission is 10 MB. Please submit no more than 9 files in any zip file regardless of size. Its important to note that some file types, like .jar and .cab may be containers and may contain files that will exceed the maximum file count.
OR
Generally, infectious files are not that large, however if a files is still suspected and is more than 10 Megabytes, it can either be split into parts and upload those or upload them to the customers FTP site. Then create a Security Response task including the path, username and password for the site.
Submission by splitting the file.
Follow the instructions in the below KB article from WinZip to split the file in to parts.
http://kb.winzip.com/kb/entry/86
Then submit the files one by one to https://submit.symantec.com/gold (Submission site to use depends on customer’s entitlement)
Collect the tracking IDs that is sent through mail.
Create a SRL task informing them about the split file submission & mention the tracking IDs.
SRL will then take over the task & proceed appropriately.
Symantec Support Tool: How to collect suspicious files and submit the samples to the Symantec Security Response Team.
http://www.symantec.com/docs/TECH147870