I opened new case about this issue.
After working with the tech for a little bit, we figured out it is an issue with the "Application & Device Control" in SEP RU5.
Systems I was having issues with:
Windows XP Pro SP3
Windows Server 2003 Standard R2 SP2
I was able to install the following components and .net framework is working:
Antivirus and Antispyware, Anvirus Email Protection - Pop/SMTP, Network Threat Protection, Proactive Threat - Trusacan
Right now wait for resolution to this issue, since I would like App & Dev Control.