Not sure, actually.  The document only says R5 or R10, the only assumption you can make is that R5 is supported on SQL Server 2005 SP2 and R10 is supported on SQL Server 2005 SP3.

I'd recommend that you contact the Symantec support team by e-mail, including your proposed environment, and explicitly asking if you will be supported.  Then you have something to fall back on (other than some forum replies) if you were ever to be denied support.

Saying that it run SQL Server 2000 on Windows 2000 makes me feel like crying.

But as Kyle stated above you would greatly benefit form a 64-bit server even with only 8GB of RAM (48 is good so you can have the entire DB in-memory ;-).


Now if you have to do that in a VM, I don't mind but there's no need to limit yourself to 32-bit (unless you are really broke and your VM infrastructure doesn't go on multi-proc server with substantial amount of memory in which case the entire virtualization subject is debatable).

Adding to this reply title I would say that even if you are limited right now have a 64-bit OS and SQL install will allow you to easily scale up on the hosted VM later on.

How many nodes are you managing?  64-bit makes sense, yes, and certainly with enough memory. (What is the point of replacing a old, underpowered server with a newer, underpowered server?)