We are also experiencing this in our environment. With the virus definitions from Feb 23, 2010 r48, you will get the Packed.Generic.271 message after some time, or you can force it by navigating to the System32 directory, then scroll down to "encdec.dll".
We have a laptop that did not pull updates, the latest was Feb 18. Navigated to the same directory, no problem. This is a false postive. The file is not corrupt, something in the latest definitions is making it flag the file.
The file encdec.dll has the same modified date (7/13/2009) as the rest of the files surrounding it in System32. So it has not been modified (compromised).
So Symantec, what do we do next?