If you have a SAN, just build your box with only local disks (2x73GBs?) for the C: drive. Allocate a fairly large LUN (maybe 100GB?) for the D: drive and this is where you will install Altiris. Depending on your SAN you may be able to configure whatever sort of RAID config you want, or take the default. If you'll be running the SQL server locally on-box (recommendation is to have a dedicated 64-bit SQL 2005 box), allocate several LUNs for drives E: ~ F: or so, and build your Altiris_CMDB database to span across those using multiple data files in the SQL configuration. Finally, allocate a couple of 10GB LUNs for the DB transaction log and TempDB.
In any case, bgreen is right on; think in terms of I/O and disk contention. When we built our first NS, we had a 36 GB RAID-1 mirror set for the OS, then a ~210GB (3x73GB) 3-disk RAID-5 with several partitions (D: for database, E: for transaction log, and F: for Altiris application). We've been suffering with that for a long time, and recently moved the database onto the SAN which has helped tremendously. Also don't forget to setup database maintenance jobs to defrag or rebuild indexes and update statistics on the database as these can help improve performance.