If they're all used at the same time? It will be nasty. But why would you use them all at the same time? There's no use-case for such a thing.
Encryption reduces performance by about 10%. SEP reduces performance (non scanning) by about 3-5%, I'm not sure about DLP that isn't my product.
All in all, it will be fine, but if you're encrypting, virus scanning and using DLP all at the same time, don't expect to get any work done