I have been poking and prodding over this for a while now, hoping to give you some good news, but I only have some speculation at this point, and haven't been able to reproduce the issue. As far as I can tell, this is a completely new, never-before-seen issue.
Jman, do you have Symantec Endpoint Protection installed? If so, what version? Did you use PGP Disk > Shred Free Space, or have it scheduled to run regularly?
Are the systems in either of your cases 32-bit? 2GB is the max file size for 32-bit systems or applications, so I am trying to see if the OS might be 32-bit or if the PGP Shredder operates in 32-bit mode. My guess would be the latter. In any case, as a file is shredded, the "pattern" might simply be the area of the drive that gets shredded, essentially creating a temp file which overwrites (shreds) the original data in that space. I would guess these temp files are typically hidden, and something is either interrupting the shredding process before the final iteration/pass (by default it is 3 passes), so the temp files don't get deleted/removed properly, or something is trying to restore files that it deems have been deleted in error, like an antivirus/security/DLP-type program. It is then 'restoring' these temporary shred files, giving them a hexidecimal suffix as they are all named the same "PGPshredpattern".
Unfortunately, I don't have more to go on at this point than hunches and educated guesses, but I am trying a variety of things in an attempt to reproduce the issue.