Hi,
Could you please test with SEP 12.1 RU2 MP1
Make sure you are not affected with the following fix id.
Server is unresponsive after installing Symantec Endpoint Protection 12.1
Fix ID: 3027951
Symptom: After installing Symantec Endpoint Protection 12.1 and rebooting, the server occasionally stops responding. A review of the memory dump shows an oplock on virscan7.dat.
Solution: Updated AutoProtect to properly read the virus definition files to avoid any thread blocks.