I am suggesting you if you are not be sure then try it in test enviornment.
If you are not have a test enviornment then create a new group and apply the same policy here.
Add the device id of that device in the exclude column.
Follow the below Symantec article to make it easy for the access.
DevViewer - a tool for finding hardware device ID for Device Blocking in Symantec Endpoint Protection
Article:TECH103401 |
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Created: 2007-01-19 |
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Updated: 2011-12-28 |
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Article URL http://www.symantec.com/docs/TECH103401 |
DevViewer --Tool helpful for Application and Device control to find Hardware Device ID and GUID
https://www-secure.symantec.com/connect/downloads/devviewer-tool-helpful-application-and-device-control-find-hardware-device-id-and-guid