Hi Thomas,
I tried FIPS in our test environment at version 10.6.0 in dec last year, not familiar with fips changes in the meantime.
My test cases included: ldaps (beware of current errors changing a data source) to ad, edir and notes for recipient validation incl custom queries, starttls opportunistic and forced in- and outbound (beware of rfc limitations of office365 and others if you offer client certs), different ms exchange versions (2010, 2013, 2016) on different versions of windows (2k8, 2k12) with different cipher settings (default, tls1.x enabled, ...), different other "clients" like sendmail, notes, etc. tcpdump will be your friend ;-)
But usually it shouldnt be a big deal except TLS and supported ciphers.
And there is still no public documentation of the used ciphers. https://support.symantec.com/en_US/article.TECH156249.html has a incomplete list, is not up2date and does not include fips.
Please let us know how and what you did.
Kind regards
Thomas