You mentioned that none of the machines have internet access, and LUA cannot be installed.
Is there any other manual way to update the definitions? ....We can download only AV/AS definitions. We cannot download rapid release definitions for PTP.
If not is it possible to easily remove Proactive Threat Protection from the clients?....Yes
How to add or remove features to existing Symantec Endpoint Protection client installations
http://www.symantec.com/business/support/index?page=content&id=TECH90936
However this applicable for few clients, if the number of clients are more and they are managed by the SEPM, then create a new package without PTP & NTP, and then push it to all clients. The AV/AS definitions can be downloaded on a different machine outside the network and the downloaded exe file can be kept at a central location within the closed network and executed on all the machines, thereby updating the virus definitions on the clients.
In case of unmanaged clients the steps mentioned in the above link should help.