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Hi,

I need some more info about environment.

Is this Issue happening on 1 machine or multiple machines??

Which version of SEP are you carrying??

If clients are manged by SEPM, check SEPM is updaetd or not ?

If it's unmanaged clients try to run liveupdate manually.

Several variables can keep the PTP definitions from updating, although when seeing the errors above can be attributed to a policy or a GPO that prevents the Symantec Endpoint Protection client from trusting the Symantec Endpoint Protection Manager for the PTP definitions. This can also prevent the updated Symcert from being trusted and installed into the Windows Certificate Store

Proactive Threat Protection definitions will not update, showing "Waiting for updates" or initial install definitions

Kindly find the below link, hope it help you..!!

https://www-secure.symantec.com/connect/downloads/ptp-services-not-working-sep

Create a new Policy move few machine in test group assign Test policy and check .

On 1 machine try running repair for sep and reboot .

Share the actual error snap. So it will help to resolve your issue.

first try below Step hope it help you

Delete the folder "SymHeurProcessProtection"

Path - HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\Symantec Endpoint Protection\AV\Storages\SymHeurProcessProtection

then Repair the Symantec after it restart the system.

Note - for the same need to stop the Symatec Services after completion startup same.

Have you tried my attach link?