Hi,
Thank you for posting in Symantec community.
Could you please provide SEP version details.
Symantec Endpoint Protection automatically deletes the files in the Quarantine when they exceed a specified age. You can configure the Quarantine to also delete files when the folder where they are stored reaches a certain size.
You can use one of the settings, or you can use both together. If you set both types of limits, then all files older than the time you have set are purged first. If the size of the folder still exceeds the size limit that you set, then the oldest files are deleted one by one. The files are deleted until the folder size falls below the specified limit.
Specify when quarantined files are automatically deleted
http://www.symantec.com/docs/HOWTO80952
The Symantec Endpoint Protection (SEP) client deletes detected files that are over 500 MB in size instead of quarantining them. This happens even when the SEP client is configured to quarantine the types of files being detected
How to delete Quarantined items from the Symantec Endpoint Protection Manager.
http://www.symantec.com/docs/TECH106444