I would test this very thoroughly before enabling. Caused me too many problems just enabling on desktops/laptops.
I would stick with AV only for Citrix/Exchange.
Best Practices for Symantec Endpoint Protection on Citrix and Terminal Servers
https://www-secure.symantec.com/connect/downloads/best-practices-symantec-endpoint-protection-citrix-and-terminal-servers
Best Practices for Installing Symantec Endpoint Protection on Windows Servers
http://www.symantec.com/business/support/index?page=content&id=TECH92440&actp=search&viewlocale=en_US&searchid=1292871908130
About the automatic exclusion of files and folders for Microsoft Exchange server and Symantec products
http://www.symantec.com/business/support/index?page=content&id=TECH102400&locale=en_US