Here's an article or two on the SIC Best Practices (just in case you've not seen them yet):
http://www.symantec.com/docs/TECH174123
http://www.symantec.com/docs/TECH172806
It's worth noting that, in general, the SIC is aimed at improving performance on virtual systems, while it sounds as if you want to use it for physiscal system too, is that correct?
If so, and while entirely possible, I've always questioned the benefit of such a setup...
A physical machine with it's own disks is likely going to be able to scan any single file faster than pinging a request to the SIC for scan results. The difference in the virtual environment is that many VMs are potentially using the same physical disks, and the network call to the SIC could all be done within the VMHost's memory. This means in the virtual environment, the overhead in the SIC call is smaller, faster, and the benefit has far greater impact.