Hello,
Yes, it surely could be done.
In SEP 11.0.RU5 or later (including SEP 12.1), any client that identifies itself to SEPM as a GUP will be added to the globallist.xml, regardless of whether they were configured as Single or Multiple GUP initially.
This globallist will be presented to clients that are configured to use a GUP. This list is applied in ascending order by the client, so if the IP Addresses are in the same subnet as the requesting client, the first one on the list will be used by that client.
In this design, clients will only attempt to contact GUPs in their own local subnet. These GUPs will never cross a router or a gateway, so if there is a router or a gateway in between the two networks then clients will only use the local GUP.
I would suggest you to check this Article:
About the types of Group Update Providers http://www.symantec.com/docs/HOWTO80957
Hope that helps!!