Endpoint Protection

What actions I should do with the replication, before that I upgrade the SEPM since v12.1.5 to 12.1.6 MP4 version. I have to servers that use the same site.

Should I only stop the  SEPM service, or  do need I to do something more. I read that some case the replication should be stop.... I need help. 
Can you give information about this?

Thanks for your help. 

You only needed to stop replication before upgrading with the 11.x version. With 12.1 you no longer need to stop replication prior to upgrading.

Upgrade or migrate to Endpoint Protection 12.1.6 - 12.1.6 MP4

Thanks Brian,

I will upgrade the first node, in this step the schema of database will be update... What will  happen with the DB when I upgrade de second node..??  What actions should I do in this step?

You just need to stop the SEPM service on both to do the upgrade. The installer is smart enough to know that DB schema is already upgraded and doesn't need to do it.

See here for the details:

Replication in 12.1 and later

For SEP 11, you had to break replication between SEPMs by deleting replication partners before perform a SEPM upgrade. Failure to break replication could result in corrupt databases. SEP 11 replication did not perform version checking. SEP 12.1 and later prevents the need to disable replication prior to upgrade. Starting with SEP 12.1, replication performs version checking, and eliminates cross-version replication corruption.

Note: When you upgrade from SEP 11 to SEP 12.1, you must still break replication.

http://www.symantec.com/docs/TECH160642