There was a discussion on this and the last thread was on March of 2010. Has there been any resolutions to this thread?
https://www-secure.symantec.com/connect/forums/safeguard-enterprise-and-sep-11-performance-issues
what version you are running on ?
upgrade to RU6; lot of issues are fixed
http://www.symantec.com/business/support/index?page=content&id=TECH131653&locale=en_US
Check this Resolved Thread
https://www-secure.symantec.com/connect/forums/sep-and-safeguard-easy-windows-delayed-write-failed
What is the version of SafeGuard Enterprise that you have? If you don't have try to upgrade to SafeGuard Enterprise 5.5