Excluding specific drives and folders from Symantec AntiVirus scans
http://service1.symantec.com/F:/ent-security.nsf/docid/2002092413394848

How to establish exclusions for custom scans and context scans.

http://service1.symantec.com/SUPPORT/ent-security.nsf/docid/2008080613075048

To set up Auto-Protect exclusions for Symantec AntiVirus clients by using Symantec System Center

Right-click a server group, server, or client group, and then click All Tasks > Symantec AntiVirus > Client Auto-Protect Options (or Client Realtime Protection Options).

Check Exclude selected files and folders and then click the lock icon so that it appears as locked.
Click Exclusions.

If you use Symantec AntiVirus 8.x, check Check for exclusions before scanning and then click the lock icon so that it appears as locked.

Click Extensions, and follow the on-screen instructions.
Add the extensions without punctuation.
Repeat the previous steps for as many extension exclusions as necessary, and then click OK.

Click Folders, and follow the on-screen instructions.

To exclude a drive, type the drive letter followed by a colon.

To set up Auto-Protect exclusions for Symantec AntiVirus servers by using Symantec System Center

Right-click a server group or server and then click All Tasks > Symantec AntiVirus > Server Auto-Protect Options (or Server Realtime Protection Options).
Check Exclude selected files and folders.
Click Exclusions.
If you use Symantec AntiVirus 8.x, check Check for exclusions before scanning.
Click Extensions, and follow the on-screen instructions.
Add the extensions without punctuation.
Repeat the previous steps for as many extension exclusions as necessary, and then click OK.
Click Folders, and follow the on-screen instructions.
To exclude a drive, type the drive letter followed by a colon.

To set up exclusions for scheduled scans by using Symantec System Center

Right-click a server group, a server, or a client group, and then click All Tasks > Symantec AntiVirus > Scheduled Scans.

Create a scheduled scan, or edit an existing scan.
Click Scan Settings.
Click Options.
In the Scheduled Scans dialog box, check Exclude files and folders, and then click Exclusions.
If you use Symantec AntiVirus 8.x, check Check file for exclusion before scanning.
Click Extensions.
Type the extension without punctuation.
Click Add, and then click OK.
Do one of the following:
If the scan affects one computer, click Files/Folders, and then check the folders to exclude.
If the scan affects more than one computer, click Folders, and then type the drive letter and full path of each folder to exclude.
Computers that do not have the excluded folders ignore the exclusion.
Click OK four times to save the scan and return to Symantec System Center.

To set up Auto-Protect exclusions on an individual computer

Start Symantec AntiVirus.
Click Configure > File System Auto-Protect (or File System Realtime Protection).
Check Exclude selected files and folders.
Click Exclusions.
If you use Symantec AntiVirus 8.x, check Check for exclusions before scanning.
Click Files/Folders.
Check the folders that you want to exclude.
Click OK.
Click Extensions.
Type the extension without punctuation, and then click Add.
Click OK.

Notes:

You cannot exclude drives from within clients.
You cannot use environmental variables, such as %windir%, to exclude folders. You must use the full path, such as C:\Winnt\.
You cannot use the wildcard characters * or ? to set exclusions.
When you exclude a folder, you also exclude all objects within that folder, including files in subfolders.

My choices are folders and extensions, not files/folders and extensions. Can I type a path to a specific file location and excluse that one particular file so as not to exclude subfolders and contents?  (Running 10.1.7)

Thanks!

Why do my options not display like those you linked to here: http://service1.symantec.com/SUPPORT/ent-security....

Not only do I not see files, I don't get the tree to select my excludes. I have to type them out, leaving room for error.

The screen that you see is On the client side for custom scans and context scans.

The steps to given above are for the server side ( SSC)
Thats the only reason that you don't see the tree :)

Well there you go! :) Thank you so much!