I had the original SAV 10.2 as it was released and from the time we went over to win 2008 late last year the server file shares kept locking up on all of our XP workstations daily. The local symantec agent for my region actually came into the office and diagnosed the problem to be the issue of auto-protect "deadlocking" the file shares.
We have been running without any antivirus on the file server (x64) or exchange server (x64) for serveral months now. To compensate I have been doing virus sweeps via the shared drives to check for any viruses.
However server 2008 x64 like vista x64 seems to have very good natural resistance to most known viruses.