James -- there seems to be some confusion -- why would you create many GPO's to push the new see clients to the client machines ??? You can create one GPO put the new packages there and apply this policy to all the OU's you want.
As if now see does not provide any hotfixes that you can apply on the client machines -- either you push packages on the machines ........ OR ......... you push upgrade packages to the client to get them on a newer version ............ OR ........ you make changes to the package .....
all these things I mentioned can be controlled by the see manager console -- hope this answers your question.