Bit of a long post here so please bear with me (btw if you're interested, you can verify each of my findings by comparing with the GUP Troubleshooting article I posted earlier):
We can see teverthing appears to be hunky dory for the most part. If you search for the below string, you can see the various log events for the GUP accepting connections for lots of various clients, and subsequently providing defs to them:
GUProxy: accepted socket
The one we're focussing on is the one below and the log events that follow it (this event shows the GUP reciving a connection from itself):
03/11 17:38:02 [3596:10508] GUProxy: accepted socket 3236 for 146.77.55.160 port 50092
Following this event, we see the below logs which state the file requested by the client, the fact that it's not present in the GUP's cache, and the GUP adding the file to its list of things to grab:
03/11 17:38:02 [3596:4712] GUPROXY - GUProxy HTTP in - GET /content/{1CD85198-26C6-4bac-8C72-5D34B025DE35}/140310033/Full.zip
03/11 17:38:02 [3596:4712] GUPROXY - GUProxy File - /content/{1CD85198-26C6-4bac-8C72-5D34B025DE35}/140310033/Full.zip
03/11 17:38:02 [3596:4712] GUPROXY - GUProxy mangled file - #content#{1CD85198-26C6-4bac-8C72-5D34B025DE35}#140310033#Full!zip
03/11 17:38:02 [3596:4712] GUProxy - Add request into download queue.
As you can tell, it appears this client (itself) has requested the full defs (called Full.zip).
The next log entry shows the download starting and how far it gets:
03/11 17:38:04 [3596:10676] GUProxy - **downloadHelper.CreateUrlRequest Succeed to GET://10.79.41.202:8014/content/{1CD85198-26C6-4bac-8C72-5D34B025DE35}/140310033/Full.zip
, begin from 0 with size 8000
03/11 17:38:04 [3596:10676] Reading query data
03/11 17:38:04 [3596:7680] A read has completed (4096 bytes)
03/11 17:38:04 [3596:7680] A read has completed (3904 bytes)
03/11 17:38:04 [3596:10676] GUProxy - Download loop, 8000 bytes were downloaded in this loop
03/11 17:38:04 [3596:10676] GUProxy - Download loop, remain 353470041 bytes to download
03/11 17:38:04 [3596:10676] Security flags set on request: 0x003100
These entries essentially combine to say that the GUP managed to download bytes 0 to 8000 of 353470041 bytes (about 337MB).
The thing is, at no point do the logs ever show it completing the download. The last logs for this particular file (Full.zip of definition revision 140310033) in the debug log show it got fairly far, but had a further 82MB to go when it errored out as below:
03/11 20:56:51 [3596:10676] GUProxy - **downloadHelper.CreateUrlRequest failed GET://10.79.41.202:8014/content/{1CD85198-26C6-4bac-8C72-5D34B025DE35}/140310033/Full.zip
, begin from 86256000 with size 4000
All in all, it looks like the SEP client is asking for the full defs, the GUP tries to download the full defs from the SEPM and fails, and so is never able to provide the defs to the SEP Client.
The connection from the SEP Client to the GUP (itself) appears fine, as the GUP seccessfully receives the request. It's unclear why the download errors though. Are there bandwidth issues between this GUP and the SEPM?
My recommendation is to update this particluar machine using the Intelligent Updater (grab it from the below link), so that it will update using deltas going forward, which appear to work going by the logs of the other connecting IP addresses.
http://www.symantec.com/security_response/definitions/download/detail.jsp?gid=savce