https://www-secure.symantec.com/connect/blogs/conf...

https://www-secure.symantec.com/connect/forums/sep...

http://www.symantec.com/business/support/index?pag...

http://www.symantec.com/business/support/index?pag...

Check above might help

Or this

1) It is possible to Virtualize the SEPM on a Virtual Machine

2) Supportability:

a) Support policy for Symantec AntiVirus Corporate Edition and Symantec Endpoint Protection on "virtual computers"

http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/e70a1327ec910cc588256e430066ee26?OpenDocument

b) About Microsoft Virtual Server support

http://seer.entsupport.symantec.com/docs/330766.htm

c) Compatibility of Symantec Endpoint Protection with Microsoft Hyper-V

http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/6788f0cd8d7db865ca2574e3007f8ed9?OpenDocument

d) Top 10 Symantec Best Practices - Deploying Symantec Endpoint Protection Architecture

http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/ab6f6bdaeabbd882ca25754b0074a662?OpenDocument

3) It is very easy to move a primary SEPM to a virtual machine - check the KB articles provided below:

a) How to point Symantec Endpoint Protection(SEP) clients to a new Symantec Endpoint Protection Manager after you have either uninstalled, are going to decommission or replace the Existing Primary Symantec Endpoint Protection Manager (SEPM).

http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/23d0a77b280a618988257567007caec1?OpenDocument

b) How do I move Symantec Endpoint Protection Manager from one server to another with a different IP address and host name?

http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/9bb60351f8fa6d3f65257409007f5774?OpenDocument

c) Best Practices guide to moving the Symantec Endpoint Protection Manager SQL Server database from an existing SQL Server database to a new SQL Server database

http://service1.symantec.com/support/ent-security.nsf/854fa02b4f5013678825731a007d06af/09ef18132cca7d4f6525742c006ba05b?OpenDocument

wow that's a comprehensive list :-)

Symantec Endpoint Protection 12.1 - Virtualization Best Practices

http://www.symantec.com/business/support/index?page=content&id=TECH173650

As a starting point have a look at this document:

Sizing and Scalability Recommendations
for Symantec Endpoint Protection
https://www-secure.symantec.com/connect/sites/default/files/Sizing%20and%20Scalability%20Best%20Practices_%20v2.3.pdf

It's not a dedicated virtualization guideline but you get an impression what you need for 10,000 clients.

many thanks to all for sharing the knowledge here :-)

Sushanta

Did above post has helped fixing your issue if any ?