Just upgraded to SEP12 recently, and it has been working fine for the most part. However, the updating of Virus Definitions stops on machines randomly. So far to correct the problem, i've had to go to the machine reporting the issue, and manually run LiveUpdate to get the definitions to update. Sometimes this solves the issue, and other times it reoccurs within 5 days. All problem machines appear to be reporting to SEP Manager just fine.
Has anyone else had this issue? and if so, how have you resolved it?