Hello,
In 12.1, Client control gives the users the most control over the client. Client control unlocks the managed settings so that users can configure them.
Client control has the following characteristics:
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Users can configure or enable firewall rules, firewall settings, application-specific settings, intrusion prevention settings, and client user interface settings.
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The client ignores the firewall rules that you configure for the client.
Client control is useful for employees who work in a remote location or a home location.
In your case, could you check if this is occuring on all machines, or specific machines?
Could you compare the policies between SEPM and Client, if they are the same and policies are being applied on the client machines?