Hi again folks, thank you for trying to help me, but please read given facts before throwing out questions.
Brian, it's a clean installation of SEPM 12.1 RU2, this was released 2012-11-15, my problems started 2012-12-05 as seen in picture "SEP 12.1 RU2 definition problem 1.PNG".
Pete, symhelp didn't report any corrupt definitions. As you can see in picture "SEP 12.1 RU2 definition problem 1.PNG" and "SEP 12.1 RU2 definition problem 2.PNG" the definitions download and install without any problems.
Pete, no cloning involved.
/Jonas