Hi,
You are correct that SEP 12.1 RU2 which is having a lot of policies and additional features.
To understand each policy check this article.
Symantec Endpoint Protection Manager - Overview - Policies explained
http://www.symantec.com/docs/TECH104436
Q. The thing is which will be more secured and which policy should be configured?
--> By default policies are configured and applied when you install SEPM. You have an option to choose Virus & Spyware policy
By default three policies are created.
Virus & Spyware Protection Policy - Balanced
Virus & Spyware Protection Policy - High Security
Virus & Spyware Protection Policy - High Performance
By default Balanced policy is assigned but to increase the level of security you can assign 'High Security' policy.
Also to increase the security you can use Application and Device control policy with more security.
Hardening Symantec Endpoint Protection (SEP) with an Application and Device Control Policy to increase security
http://www.symantec.com/docs/TECH132337
The screen shot you attached is all about new features added in SEP 12.1 like SONAR, Download insight, Early Launch Anti-Malware Driver.
Check this article to know more about it.
What's new in version 12.1
http://www.symantec.com/docs/HOWTO55189
What is new in Symantec Endpoint Protection 12.1?
http://www.symantec.com/docs/TECH163413