Hi,
Thank you for posting in Symantec community.
I would be glad to answer your query.
What's the SEPM DB size (sem5.db)? What's the difference between both the test environment because only one upgrade is affected? I would suggest to keep it under observation because as part of the upgrade to SEPM 12.1 RU5, the SEPM converts all of the content from full definitions to delta definitions. This process is resource intensive and may take an extended period of time. After this process is completed, the SEPM will use significantly less disk space.
In a typical enterprise setup where 30 content revisions stored, the SEPM upgrade process must reduce 55GB of full content to under 2GB of delta content. This process requires significant resources to complete and is impacted by the performance of any available CPUs, CPU cores (physical/logical/hyperthreading), memory, and disks (I/O). On a server that performs multiple roles, stores larger numbers of content, or is otherwise resource constrained, this process may take a longer duration to complete.
Refer this article to find more info: The LiveUpdate content optimization and content storage space optimization steps take a long time to complete when upgrading to Symantec Endpoint Protection Manager 12.1 RU5
http://www.symantec.com/docs/TECH224055