Ok here is the error.
2015-07-07T10:15:16.122Z ERROR I SIS ContentId=[VirusDefs]
2015-07-07T10:15:16.122Z ERROR I SIS DeferralGuid=[{FE653A5C-B5B8-4273-B2C6-B5DFB93C0BEC}]
2015-07-07T10:15:16.122Z ERROR I SIS SrcPath=[C:\Windows\TEMP\ee09ea97-4712-47d2-93b3-3188d26757ba\VDefs.zip]
2015-07-07T10:15:16.122Z ERROR I SIS DestPath=[C:\ProgramData\Symantec\Symantec Endpoint Protection\12.1.6168.6000.105\Data\Definitions\]
2015-07-07T10:15:16.122Z ERROR I SIS OnFail=[rollbackExecution]
2015-07-07T10:15:16.122Z ERROR I SIS CopyMode=[Move]
Now I would suggest you to first run clean wipe and then delete the following folder C:\ProgramData\Symantec\Symantec Endpoint Protection\12.1.6168.6000.105\Data\Definitions\
and try installing SEP 12.1.6
if it's still failing
would suggest you to first run clean wipe and then delete the following folder
C:\Windows\TEMP\ee09ea97-4712-47d2-93b3-3188d26757ba\VDefs.zip
C:\ProgramData\Symantec\Symantec Endpoint Protection\12.1.6168.6000.105\Data\Definitions\
and try installing SEP 12.1.6