Hello,
Yes SEP 12.1 RU2 is the first version of SEP that is compatible with Windows 8 and Windows Server 2012.
What's new in Symantec Endpoint Protection 12.1.2
http://www.symantec.com/docs/HOWTO81091
Symantec Endpoint Protection now supports additional new platforms and configurations.
You can now install Symantec Endpoint Protection Manager on the following operating systems:
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Windows 8
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Windows Server 2012
You can now install the Symantec Endpoint Protection client on the following operating systems:
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Windows 8 and Windows Server 2012
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Mac OS X 10.8, Mountain Lion
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Mac OS X case-sensitive formatted volumes
You can now use Symantec Endpoint Protection Manager from the following browsers:
In case you are planning to upgrade or migrate to Symantec Endpoint Protection 12.1.2, please take a look at the latest how-to article created by our very own SEP content council team.
Best practices for upgrading to Symantec Endpoint Protection 12.1.2
http://www.symantec.com/docs/TECH163700
Hope that helps!!