Hi there,
It's my understanding that the newer build should install over the older 12.1 build without any need to uninstall.
Here's some good information:
Symantec Endpoint Protection for Macintosh Frequently Asked Questions (SEP for Mac FAQ)
http://www.symantec.com/docs/TECH134203
...
Q. How do I install SEP for Mac?
A. Installing the Symantec Endpoint Protection client for Mac covers both managed and unmanaged installations. Push deployment from the SEPM (using the Client Deployment Wizard) is supported as of Symantec Endpoint Protection 12.1.5.
Q. I already have a Symantec antivirus / security product on my Mac. Do I have to uninstall it first before installing SEP for Mac?
A. Legacy SEP 11 installations, managed or unmanaged, do not need to be uninstalled first unless your are also updating your version of OSX (see "What if I wish to perform a major upgrade to Mac OS X with SEP installed?" above). Symantec AntiVirus for Macintosh and consumer products Norton AntiVirus and Norton Internet Security for Macintosh must be uninstalled first. Please see the following document for details: Supported upgrade and migration paths to Symantec Endpoint Protection 12.1.x.
Q. What about upgrading SEP for Mac to a newer version? Can I use Upgrade Groups with Package (auto-upgrade)?
A. Unfortunately, you must export a client package for the new version then install or deploy as you would a new installation; it is not possible to use the Upgrade Groups with Package wizard (auto-upgrade) to migrate Macintosh clients up to a later client version. However, you can install the new version directly over the old without uninstalling first.
Q. There's no Add or Remove programs for Mac. How do I uninstall?
A. There is an uninstaller included on the SEP installation media; look under SEP_MAC, for SymantecUninstaller.English.tgz. Copy this file to the local Mac client and double-click on it to expand. Inside are two items: Symantec Uninstaller (which is the actual uninstaller), and SymantecUninstaller.pkg (which will actually install the Uninstaller to your hard drive; installing the Uninstaller is not necessary). The Uninstaller is intended for all Symantec products on the Mac, not just SEP. For more information, please see this document: How to uninstall Symantec Endpoint Protection for Macintosh.
All the best,
Mick