Hi Buckeye1,
"Thumbs up" to the above.
Besides: applying patches against all known vulnerabilities is an important part of maintaining computer security. There haven't been any new patches for Win2K in years. If a threat did come along which operates by exploiting a known vulnerability, and SEP 12.1 wasn't working correctly for some reason (it was not tested/certified to be working perfectly on Win2K), that machine and everything on it could be compromised. Even if it was somehow possible to get 12.1 onto 2000, I would not stake my company's wellbeing on a seceurity solution that had been hacked-on.
Symantec Endpoint Protection – Best Practices
http://www.symantec.com/theme.jsp?themeid=stopping_malware&depthpath=0
Hope this helps!
Mick