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When the client software scans a suspicious file, it places the file in the local Quarantine folder on the infected computer. The Quarantine clean-up feature automatically deletes the files in the Quarantine when they exceed a specified age. The Quarantine clean-up feature automatically deletes the files in the Quarantine when the directory where they are stored reaches a certain size.
You can configure these options using the Antivirus and Antispyware Policy. You can individually configure the number of days to keep repaired, backup, and quarantined files. You can also set the maximum directory size that is allowed before files are automatically removed from the client computer.
You can use one of the settings, or you can use both together. If you set both types of limits, then all files older than the time you have set are purged first. If the size of the directory still exceeds the size limit that you set, then the oldest files are deleted one by one. The files are deleted until the directory size falls below the limit. By default, these options are not enabled.
How to Manage Quarantined files.
http://www.symantec.com/docs/TECH106443
How to delete Quarantined items from the Symantec Endpoint Protection Manager.