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The protection technologies in Symantec Endpoint Protection Manager and Symantec Endpoint Protection typically function the same way in virtual infrastructures as they do in physical infrastructures. You can install, configure, and use Symantec Endpoint Protection Manager and Symantec Endpoint Protection clients in virtual infrastructures in the same way as in physical infrastructures.
If you are running a non-persistent VDI setup then you should consider the following additional items.
You can then configure a separate purge interval in Symantec Endpoint Protection for the offline guest virtual machines (GVMs) in non-persistent virtual desktop infrastructures. Symantec Endpoint Protection Manager removes the non-persistent GVM clients that have been offline longer than the specified time period. This feature makes it simpler to manage the non-persistent GVMs in Symantec Endpoint Protection Manager.
Symantec Endpoint Protection 12.1 - Non-persistent Virtualization Best Practices
http://www.symantec.com/docs/TECH180229
Supported virtual installations and virtualization products
http://www.symantec.com/docs/HOWTO55136
Check the attached PDF also.