Hi Sach007,
Replication Best Practices:
1. For more than 3 sites or 1,000 clients: No more frequent replication than once per day
2. Versions of the Policy Manager have to be the same.
3. Replication schedules should not overlap.
4. If replicating over WAN, only replicate the logs.
5. Number of replicated sites should ideally be kept below 5. Ratio will be 1:4 ( i.e 1 primary : 4 seconday )
6. The value of “Content revisions to keep” should be set to a lower value.
7. If you have configured multiple replication partner then always make sure that the replication schedules won't overlap .This situation can lead to Database Deadlock issues.
8. Delete Replication Partners when
1.Upgrading the Policy Manager.
2.If any CRT Approved tools need to executed.
3.Software / Hardware maintenance on the Policy Manager.
4.Backing up database manually.
Reference: