We have similar issue it occurs everyday. We have 400 servers mainly 2008 R2 running latest client 12.1.6 MP5. Randomly about 20 - 40 servers have problem with scanning which stuck or hang for multiple days, that cause Virus Definitions Not updating and the new daily scheduled scan doesn't run.
We have to reboot the servers for temporary resolve the problem, however, the problem will re-occur in few days later.
We have tried reinstalling the client but without luck.
It seems like it's a bug on SEP client version 12.1.6 MP5.
Any Symantec employee can provide any suggestion?