when a infection is sitting inside a compressed file it cannot attack the computer where it is lying until and unless it is decompressed, that's the reason symantec also recommends you to send in your virus samples in zipped file.
on the other hand even if there is an infection sitting inside a compressed file when a user or a process tries to extract/use the infected file, your auto protect will kick in to protect your PC, provided symantec is able to detect that specific infection.
to be sure try downloading the ecairs test samples and put it into compressed file and the try decompressing it.