try this
For the SEPM 12.X, which has internet access:
1. Uninstall LiveUpdate via Add/Remove Programs and then reinstall by running Lusetup.exe from the SEP installation media, or downloading the latest client from the article referenced below.
2. Open a command line, Start > Run > CMD
Navigate to C:\Program Files\Symantec\Symantec Endpoint Protection Manager\Bin
3. Type in the following commands
lucatalog.exe -cleanup
lucatalog.exe -forcedupdate
4. The .JDB should now be able to update the SEPM's Virus Definitions