You mentioned that the clients are experiencing slow responses since SEPM was installed. SEPM does not have a scanning functionality.
You will need to have a SEP client to have scans on the server.
I agree with SAM. You can create centralized exceptions on the server for the Oracle DB files.
Also, on a server OS, you should install only AV/AS part of a SEP client.
Cheers,
Aniket