Yes, it works fine for 12.1 client. The RU2 has a *NEW* push communication setting which helps for rescanning back originally managed client by 12.1.671. It's very handy.
I do like to thank for helps here.
There are two points which I like to share though.
In order for scanning work, the ICMP has to be allowed from SEPM to the client desktop Vlans.
And I also have been wondering, is SAV 11 not supported in 12.1 RU2? Cos I cannot find the virus definition can be "choose" from the download content tab.
~Many thanks