Hi JayM,
With default settings and policies, there should be no trouble at all with a SEP 12.1 client and MS SQL. It should not interfere with MS SQL's processes, files, or databases.
You may wish to create manual exceptions if you have any suspicion that SEP is related to the crash. Here are a couple of articles that may be of interest.
Can Symantec AntiVirus or Symantec Endpoint Protection scan a MS SQL database?
Article URL http://www.symantec.com/docs/TECH100129
How to exclude MS SQL files and folders using Centralized Exceptions
Article URL http://www.symantec.com/docs/TECH105240
Final note: MS SQL 2000 is a product long retired by its manufacturer. You may wish to upgrade to a supported version if any critical business datbases are still using MS SQL 2000.
Hope this helps!