I haven't seen any issues with it. I changed from one NS to another at one point after I installed 7.1 SP2 MP1 myself. Granted, I was going from one 7.1 install to another (we had Asset and CMS separate, but then consolidated), but all you need to do is define the SMP from your SD install and set it as the primary. I believe you would also need to restart the server extensions and IIS to make it fully transfer to the new one, but it was a pretty trivial process if I remember correctly.