This is just an observation, and may needed to be tested on more servers
We were running the ServiceDesk v7.2 and were noticing that the RAM usage was pretty high. Server had 16GB on it and almost always was running close to 15GB, CPU wasn't very busy 70~80%, but there was high disk activity, page file usage and other indicators that we decided to add more RAM.
Well, we added another 16GB (just because it was cheap), and right off the bat, we noticed the server started to max out around 12GB, (same user load and all other variables). It was kind of surprising and lesson learned at the same time that we did not need another 16GB, could have been fine with just an additional 4GB.
Anyway this is what we observed and I wanted to share with other SD admin that might be facing similar situation.