Hello,

Did you say "All SEP clients lost  the  connection with servies.msc at the local machine because of that  its indicated as disabled in the client pc and also lost the connection with symantec management."

So, are the client machines able to access the services.msc now? Was that because of a GPO on your environment?

Secondly, How many client machines do you have in all which are not communicating to the SEPM server?

Here are Troubleshooting documents for SEP 12.1 - 

Troubleshooting communication problems between the management server and the client

http://www.symantec.com/docs/HOWTO55017

Troubleshooting communication problems between the management server and the console or the database

http://www.symantec.com/docs/HOWTO55032

Recovering client communication settings by using the SylinkDrop tool

http://www.symantec.com/docs/HOWTO55428

Recovering client communication settings by using the SylinkReplacer tool (available with Symantec Technical Support)

http://www.symantec.com/docs/TECH105211

To get SylinkReplacer for SEP 12.1 Utility, you will have to call symantec or log a web case.

QuickStart Guide - Create and Manage Support Cases in SymWISE

http://www.symantec.com/docs/HOWTO31132

How to update a support case and upload diagnostic files with MySupport

http://www.symantec.com/docs/TECH71023

OR

Regional Support Telephone Numbers:

United States: 800-342-0652 (407-357-7600 from outside the United States)

Australia: 1300 365510 (+61 2 8220 7111 from outside Australia)

United Kingdom: +44 (0) 870 606 6000

Additional contact numbers: http://www.symantec.com/business/support/contact_techsupp_static.jsp

Hope that helps!!

Hi  Mithun,

My  3 - 4 clients have this  problem,  same   clients   cant  communicate with  management and also  services.msc of local machine,it partialy  dead , once we try  to   open  the client in  the  local  machine sep       got  replay  that  "symantec has  stopped"