Hello,
Could you please let us know the OS on which you are facing the high I/O??
How much Ram does the machines carry on themselves??
Are these clients virtual machines??
Could you try disabling startup scan, active scan when new definitions arrive, network files scan, to minimize the SEP effect on PC performance.
1. Disable startup scan and active scan when new definitions arrive, go to Virus and Spyware Protection policy-->Administrator-Defined Scans-->Advanced.
2.Disable network files scan,go to Virus and Spyware Protection policy-->Auto-Protect-->Scan details-->Network settings
3.Disable file cache or disable rescan cache when new definitions load,go to Virus and Spyware Protection policy-->Auto-Protect-->Advanced-->file cache
Hope that helps!!