Still researching, but no resolution. Here is a brief update.
The issue is caused by an open IRP between ComputerA and ComputerB. ComputerA shows an active connection with ComputerB, but ComputerB shows no connection. ComputerB shows no crash or issue at all. Because the connection is performing a WrPageIn operation, the system cannot close the connection. Hence the hang.
We had a call between our company, Symantec and Microsoft. Microsoft stated that Symantec was doing everything correctly. Microsoft believes there is a device between ComputerA and ComputerB that did not honor the disconnect between the two and, instead, keeping the connection open.
This weekend, we turned on network capturing in an attempt to see what the systems are doing and possibly where the issue is occuring.
This issue seems to happen when Package Servers retrieve packages across a WAN connection. We have many device in between, most notibly a SonicWALL device that may be performing many actions on the packets, including Deep Packet Inspection (DPI).
Interestingly, the failures always happen on XML files in the Patch Windows System Assessment Scan Tool Package.
Go here for a little more detail.