Disk Space Management procedures for the SEPM
http://www.symantec.com/business/support/index?pag...

it is recommended to utilize the following articles for additional information:

1) Disk Space Management procedures for the Symantec Endpoint Protection Manager

http://www.symantec.com/docs/TECH96214

2) Symantec Endpoint Protection virus definition folder consumes a large amount of disk space

http://www.symantec.com/docs/TECH102927

3) For information on monitoring Server Health from Symantec Endpoint Protection Manager and Receive Notification, view the article linked below:

Monitoring Server Health on Symantec Endpoint Protection Manager

http://www.symantec.com/docs/TECH122731

Some Best Practice Articles:

1) Best Practices for configuring the number of content revisions to keep in Symantec Endpoint Protection Manager

http://www.symantec.com/docs/TECH92225

2) Troubleshooting Content Delivery to the Symantec Endpoint Protection client

http://www.symantec.com/docs/TECH106034

Hi,

IF your DB is embedded DB You can refer below link:-

First try Disk Space Management procedures for the Symantec Endpoint Protection Manager

http://www.symantec.com/docs/TECH96214

How to Shrink the Symantec Endpoint Protection Manager 12.1 embedded database

https://www-secure.symantec.com/connect/downloads/...

Regards,
Zafar

What sub-folders on the drive can you observe taking that space?

The most space will be taken by the AV definitions kept on SEPM - have a look at the following articles and set the amount of the definitions kept as appropriate:

http://www.symantec.com/docs/TECH92225

http://www.symantec.com/docs/TECH103956

How many content revisions are you keeping?

Go to Admin > Servers > Local Site server right click edit properties > Liveupdate check number of content revisions to be keep. If this is set high then more space will be used especially if store clients unzipped is ticked for better performance.

Hello,

Please let me know if any more help require?