@Brian
I have run the SymHelp.exe on both a managed client and the SEPM server. I have posted some screen caps below. Only thing that could maybe cause an issue is the SEPM sever compains that Java and SQL are using the same ports, but it uses those 2 programs to run, so not sure on that one.
@Rafeeq
I dont see any errors complaining of full disk space on the log. The partition SEPM runs on has ~60GB free at this time. I also verfied NTFS permissions are correct but no change.
@Swapnil
I tried the date format change, did not seem to have any affect. SEPM is getting definition updates for everything, and is also pushing them out. I can see all the definitions update from day to day on the clients, so SEPM and the clients are staying current, its just SEPM is erroring because it sees the signatures as "Not Available".
I did some searching and it looks like 12.1 RU1 had an issue with the SQL database that was causing an issue just like this. I know at sometime before we updated to 12.1 RU5 we ran SrinkEmbeddedDB to cleanup the embedded database. Could that have caused an issue?
SymHelp grabs:
Client
SEPM