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This issue is fixed in version RU6a and will be inclusive of future releases.
Possible workarounds:
1. Create a new Application and Device Control (ADC) Policy without any rule changes and apply it to the affected group. Update the policy on the client and restart the affected computers. (Note: Withdrawing the ADC policy should also work.)
2. Alternatively create a new group and delete the ADC Policy for that group, then move clients to that group.
2. Roll the client back to 11.0.4202.75.
Title: 'After migrating a Symantec Endpoint Protection (SEP) 11 client to Release Update (RU) 5 or installing RU5, .NET Framework applications fail to work properly.'
Document ID: 2010012709305848
> Web URL:
http://service1.symantec.com/support/ent-security.nsf/docid/2010012709305848?Open&seg=ent