Kindly check with the articles:
For Excluding files and folders for autoprotect scan(Real time scan) and for scheduled scans:
How to create exclusions for files in Symantec AntiVirus 10.x and Symantec Client Security 3.x for Client Auto Protect (Realtime Scan).
http://www.symantec.com/business/support/index?page=content&id=TECH103090
How to create exclusions for files in Symantec AntiVirus 10.0 and Symantec Client Security 3.0 for Client Scheduled Scans
http://www.symantec.com/business/support/index?page=content&id=TECH103089
* As the configuration propogates from the server group level to the client level,if you apply this configuration on the server group - it will be applied to the primary server,secondary servers(if any) and their respective clients.
* And if you configure it to the primary server or any of the secondary servers, it is applicable for parent server(primary or the secondary on which you have configured) and its own clients.
* If you want to configure it on only one client,right click on that specific client and it will be applied.